THE TRAUNER RESEARCH GROUP

2024-06-18

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Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition

Andrews, S. P.; Ball, M.; Wierschem, F.; Cleator, E.; Oliver, S.; Hogenauer, K.; Simic, O.; Antonello, A.; Hunger, U.; Smith, M. D.; Ley, S. V. Chem. Eur. J. 2007, 13, 5688–5712.

2024-06-12

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Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition–Intramolecular Aldol Reaction

Mitsugi, K.; Takabayashi T.; Ohyoshi T.; Kigoshi H. Org. Lett. 2022, 24, 4635–4639.

2024-05-29

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Total Synthesis of Aleutianamine

H. Yu, Z. P. Sercel, S. P. Rezgui, J. Farhi, S. C. Virgil, B. M. Stoltz J. Am. Chem. Soc. 2023, 145, 25533-25537.

2024-05-22

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Total Synthesis of (−)-Batrachotoxin Enabled by a Pd/Ag-Promoted Suzuki–Miyaura Coupling Reaction

Watanabe, Y.; Morozumi, H.; Mutoh, H.; Hagiwara, K.; Inoue. M. Angew. Chem. Int. Ed. 2023, 62, e202309688.

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2024-05-12

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Total Synthesis of Putative Melognine

Irie, Y.; Yokoshima, S. J. Am. Chem. Soc. 2024, 146, 9526–9531.

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2024-05-08

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Total Synthesis of Resiniferatoxin

Vasilev, V. H.; Spessert, L.; Yu, Kuan; Maimone T. J. J. Am. Chem. Soc. 2022, 144, 36, 16332–16337.

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2024-05-01

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Total Syntheses of (−)-Conidiogenone B, (−)-Conidiogenone, and (−)-Conidiogenol

Xu, B.; Xun, W.; Su, S.; Zhai, H. Angew. Chem. Int. Ed. 2020, 59, 16475.

2024-04-24

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Asymmetric Total Synthesis of (2R)‑Hydroxynorneomajucin, a Norsesquiterpene from Illicium jiadifengpi

Dooley III, C.J.; Rychnovsky, S. D. Org. Lett. 2022, 24, 18, 3411 – 3415

2024-04-09

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Total Synthesis of (±)-Isostemofoline

Kende, A. S.; Smalley, T. L.; Huang, H. J. Am. Chem. Soc.1999, 121, 7431–7432.

2024-04-02

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Platinum- and Gold-Catalyzed Rearrangement Reactions of Propargyl Acetates: Total Syntheses of (−)-α-Cubebene, (−)-Cubebol, Sesquicarene and Related Terpenes.

Fürstner, A.; Hannen, P., Chem. Eur. J., 2006, 12, 3006-3019

2024-03-27

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Divergent Asymmetric Total Synthesis of (−)-Voacafricines A and B

Andres, R; Wang, Q; Zhu, J. Angew. Chem. Int. Ed.,2023, 62, e202301517

2024-03-20

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Aza-Cope Rearrangement–Mannich Cyclizations for the Formation of Complex Tricyclic Amines: Stereocontrolled Total Synthesis of (±)-Gelsemine

Earley, W. G.; Jacobsen, J. E.; Madin, A.; Meier, P.; O’Donnell, C. J.; Oh, T.; Old, D. W.; Overman, L. E.; Sharp, M. J. J. Am. Chem. Soc. 2005, 127, 18046–18053

2024-03-13

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Total Synthesis, Relay Synthesis, and Structural Confirmation of the C18-Norditerpenoid Alkaloid Neofinaconitine

Shi, Y.; Wilmot, J. T.; Nordstrøm, L. U.; Tan, D. S.; Gin, D. Y. J. Am. Chem. Soc. 2013, 135, 14313-14320

2024-03-06

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Diastereoselective Synthesis of trans-anti-Hydrophenanthrenes via Ti-mediated Radical Cyclization and Total Synthesis of Kamebanin.

Suzuki, T.; Ikeda, W.; Kanno, A.; Ikeuchi, K.; Tanino, K. Chem. Eur. J. 2023, 29, e202203511

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2024-02-28

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Enantioselective Syntheses of Wickerols A and B

Chung, J; Capani, J. S; Göhl, M; Roosen, P. C; Vanderwal C. D. J. Am. Chem. Soc. 2023, 145, 6486–6497

2024-02-21

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Synthesis of Pleuromutilin

Foy, N. J.; Pronin S. V.; J. Am. Chem. Soc. 2022, 144, 10174–10179.

2024-02-14

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A Concise Total Synthesis of (+)-Waihoensene Guided by Quaternary Center Analysis

Peng, C.; Arya, P.; Zhou, Z.; Snyder, S. Angew. Chem. Int. Ed. 2020, 59, 13521 – 13525.

2024-02-07

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Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A

Xu, B.; Liu, C.; Dai M. J. Am. Chem. Soc. 2022, 144, 19700−19703.

2024-01-31

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Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations

Nicolaou, K. C.; Wang, Y.; Lu, M.; Mandal, D.; Pattanayak, M. R.; Yu, R.; Shah, A. A.; Chen, J. S.; Zhang, H.; Crawford, J. J.; Pasunoori, L.; Poudel, Y. B.; Chowdari, N. S.; Pan, C.; Nazeer, A.; Gangwar, S.; Vite, G.; Pitsinos, E. N. J. Am. Chem. Soc. 2016, 138, 8235–8246.

2024-01-24

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Total Synthesis of Strychnine

Lee, G. S.; Namkoong, G.; Park, J.; Chen. D. Y.-K. Chem. Eur. J. 2017, 23, 16189–16193.

2024-01-17

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Total Syntheses of Scabrolide A and Yonarolide

Serrano, R.; Boyko, Y. D.; Hernandez, L. W.; Lotuzas, A.; Sarlah, D. J. Am. Chem. Soc. 2023, 145, 8805–8809.

2024-01-10

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Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

Clementson S.; Jessing M.; Pedersen H.; Vital P.; Kristensen J. P. J. Am. Chem. Soc. 2019, 141, 8783-8786

2023-12-20

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Bent π-Conjugation within a Macrocycle: Asymmetric Total Syntheses of Spirohexenolides A and B

Guo, L.-D.; Wu, Y.; Xu, X.; Lin, Z.; Tong, R. Angew. Chem. Int. Ed. 2023, e202316259

2023-12-13

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Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

Shen, Y.; Li, L.; Xiao, X.; Yang, S.; Hua, Y.; Wang, Y.; Zhang, Y.-W.; Zhang, Y. J. Am. Chem. Soc. 2021, 143, 3256–3263.

2023-12-06

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Total Synthesis of (+)-Fendleridine (Aspidoalbidine) and (+)-1-Acetylaspidoalbidine

Campbell, E.L.; Zuhl, M.; Liu, C.M.; Boger, D. J. Am. Chem. Soc. 2010, 132, 3009-3012.

2023-11-29

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Enatioselective Total Synthesis of the Cephalotaxus Alkaloids (-)-Fourtuneicyclidine A and B and (-)-Cephalotine B

Sheng, P-Z.; Ni, Z-B.; Li, L-L.; Wei, K.; Zhang, H.; Yang, Y-R. Org. Lett. 2023, 25, 7464-7469.

2023-11-15

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Asymmetric Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor

Shao, A.; Liu, W.; Liu, M.; He, H.; Zhou, Q.-L.; Zhu, S.-F.; Gao, S. J. Am. Chem. Soc. 2023, 145, 25086-25092.

2023-11-09

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Enantioselective Total Synthesis of (-)-Maoecrystal V

Zheng, C.; Dubovyk, I.; Lazarski, K. E.; Thomson, R. E., J. Am. Chem. Soc. 2014, 136, 17750-17756

2023-11-08

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Total synthesis of (-)-Nummularine F

Heffner, R. J.; Jiang, J.; Joullie, M. M. J. Am. Chem. Soc. 1992, 26, 10181–10189.

2023-11-01

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Total Synthesis of dl-Coriolin

Danishefsky, S.; Zamboni, R.; Kahn, M.; Etheredge S. J. J. Am. Chem. Soc. 1980, 102, 6, 2097–2098.

2023-10-25

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Total Synthesis of (+)-Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of its Absolute Configuration

Odagi, M.; Yamamoto, Y.; Nagasawa, K. Angew. Chem. Int. Ed. 2018, 57, 2229-2232

2023-10-18

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Total Synthesis of (+)-Aberrarone

Wang, Y.; Su, Y; Jia, Y. J. Am. Chem. Soc. 2023, 145, 9459–9463.

2023-10-11

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Synthesis of a limonoid, azadiradione

Corey, E. J.; Hahl, R. W. Tetrahedron Lett. 1989, 30, 3023–3026.

2023-10-04

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Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine

Qi, X.; Bao, H.; Tambar, U. K. J. Am. Chem. Soc. 2011, 133, 10050–10053.

2023-09-27

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Enantioselective Total Synthesis of (−)-Pavidolide B

Zhang, P.; Yan, Z.; Li, Y.; Gong, J.; Yang, Z. J. Am. Chem. Soc. 2017, 139, 13989−13992.

2023-09-20

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Synthesis of ent-Ketorfanol via a C-H Alkenylation/Torquoselective 6𝝿 Electrocyclization Cascade

Phillips, E. M.; Mesganaw, T.; Patel, A.; Duttwyler, S.; Mercado, B. Q.; Houk, K. N.; Ellman, J. A. Angew. Chem. Int. Ed. 2015, 54, 12044-12048.

2023-09-13

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Total Synthesis of the Isodon Diterpene Sculponeatin D

Moritz, B. J.; Mack, D. J.; Tong, L.; Thomson, R. J. Angew. Chem. Int. Ed. 2014, 53, 2988–2991.

2023-09-06

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Total Synthesis of Rubriflordilactone B

Yang, P.; Yao, M.; Li, J.; Li. Y; Li. A. Angew. Chem. Int. Ed. 2016, 55, 6964–6968.

2023-08-30

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Total Synthesis of Isorosthin L and Isoadenolin I

Ao, J.; Sun, C.; Chen, B.; Yu, N.; Liang, G. Angew. Chem. Int. Ed. 2022, 61, e202114489.

2023-08-23

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Scalable Total Synthesis of Portimine A and B Reveals the Basis of Their Potent and Selective Anti-cancer Acitvity

Tang, J.; Li, W.; Chiu, T.-Y.; Lou, Z.; Chong, C. T.; Wei, Q.; Martinez-Peňa, Gazaniga, N.; See, Y. Y.; Lairson, L. L.; Parker, C. G.; Baran, P. S. Chemrxiv, 2023

2023-08-16

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Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core

Kurose, T.; Tsukano, C.; Nanjo, T.; Takemoto, Y. Org. Lett. 2021, 23, 676–681.

2023-08-09

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Concise asymmetric synthesis of (−)-bilobalide

Baker, M. A.; Demoret, R. M.; Ohtawa, M.; Shenvi, R. A. Nature 2019, 575, 643–646.

2023-08-02

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Enantioselective Total Synthesis of (+)-Stephadiamine

Yang, B.; Li, G.; Wang, Q.; Zhu, J. J. Am. Chem. Soc. 2023, 145, 5001–5006

2023-07-26

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Asymmetric Total Synthesis of Illisimonin A

Etling, C.; Tedesco, G.; Di Marco, A.; Kalesse, M. J. Am. Chem. Soc. 2023, 145, 7021-7029.

2023-07-19

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Total Synthesis of (+)-Fawcettidine

Kozak, J. A.; Dake, G. R. Angew. Chem. Int. Ed. 2008, 47, 4221–4223.

2023-07-12

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Oxidative Entry into the Illicium Sesquiterpenes: Enantiospecific Synthesis of (+)-Pseudoanisatin

Hung, K.; Condakes, M.; Morikawa, T.; Maimone, T. J. J. Am. Chem. Soc. 2016, 138, 16616–16619

2023-07-05

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Total Synthesis of (-)-Sinularadiolide. A Transannular Approach

Meng, Z.; Fürstner, A. J. Am. Chem. Soc. 2019, 141, 805-819.

2023-06-28

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Assembly of the Limonoid Architecture by a Divergent Approach: Total Synthesis of (±)-Andirolide N via (±)-8α-Hydroxycarapin

Schuppe, A. W.; Newhouse, T. R. J. Am. Chem. Soc. 2017, 139, 631–634.

2023-06-21

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Enantioselective Total Synthesis of (−)-Limaspermidine and (−)-Kopsinine by a Nitroaryl Transfer Cascade Strategy

Horst, B.; Verdoorn, D. S.; Hennig, S.; van der Heijden, G.; Ruijter, E. Angew. Chem. Int. Ed. 2022, 61, e202210592.

2023-06-14

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Total Synthesis of (±)-Waihoensene

Lee, H.; Kang. T.; Lee H.-Y. Angew. Chem. Int. Ed. 2017, 56, 8254-8257.

2023-06-07

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Total Synthesis of (–)-Gardmultimine A

Che, P.; Yang, H.; Zhang, H.; Chen, W.; Zhang, Z.; Zhang, J.; Li, H.; Wang, X.; Xie, X.; She, X. Org. Lett. 2020, 22, 2022–2025

2023-05-31

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Asymmetric Total Synthesis of (+)-6-epi-Castanospermine by the Stereoselective Formation of a syn,anti Acetylenic 2-Amino-1,3-diol Stereotriad

Louvel, J.; Botuha, C.; Chemla, F.; Demont, E.; Ferreira, Fr.; Pérez-Luna, A. Eur. J. Org. Chem. 2010, 2921–2926.

2023-05-24

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A Concise Synthesis of Pleurotin Enabled by a Nontraditional C-H Epimerization

Hoskin, J. F.; Sorensen, E. J. J. Am. Chem. Soc. 2022, 144, 14042-14046

2023-05-17

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Total Synthesis of the Tetracyclic Pyridinium Alkaloid epi-Tetradehydrohalicyclamine B

Dalling, A. G.; Späth, G.; Fürstner, A. Angew. Chem. Int. Ed. 2022, 61, e202209651.

2023-05-10

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Combined C−H Activation/Cope Rearrangement as a Strategic Reaction in Organic Synthesis: Total Synthesis of (−)-Colombiasin A and (−)-Elisapterosin B

Davies, H. M. L.; Dai, X.; Long, M. S. J. Am. Chem. Soc. 2006, 128, 2485–2490.

2023-05-03

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Total Synthesis of the Akuammiline Alkaloid Picrinine

Smith, J. M.; Moreno, J.; Boal, B. W.; Garg, N. K. J. Am. Chem. Soc. 2014, 136, 4504–4507.

2023-04-26

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10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D

Jackson, J. J.; Kobayashi, H.; Steffens, S. D.; Zakarian, A. Angew. Chem. Int. Ed. 2015, 54, 9971−9975.

2023-04-19

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Total Synthesis of Bipolamine I

Qiu, X.; Pierce, J. G. J. Am. Chem. Soc. 2022, 144, 12638–12641.

2023-04-12

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The Total Synthesis of (+)-Shearilicine

Kim, D.; Zhy, Y.; Harada, S.; Aguilar, I.; Cuomo, A.; Wang, M.; Newhouse, T. R. J. Am. Chem. Soc. 2023, 145, 4394−4399.

2023-04-05

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Total Synthesis of Abyssomicin C and atrop-Abyssomicin C

Nicolaou, K. C.; Harrison, S. T. Angew. Chem. Int. Ed. 2006, 45, 3256–3260.

2023-03-29

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Total Synthesis of Dapholdhamine B and Dapholdamine B Lactone

Guo, L.-D.; Hou, J.; Tu, W.; Zhang, Y.; Zhang, Y.; Chen, L.; Xu, J. J. Am. Chem. Soc. 2019, 141, 11613–11720.

2023-03-22

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Enantioselective Synthesis of (−)-Maoecrystal V by Enantiodetermining C–H Functionalization

Lu, P.; Mailyan, A.; Gu, Z.; Guptill, D. M.; Wang, H.; Davies, H. M. L.; Zakarian, A. J. Am. Chem. Soc. 2014, 136, 17738–17749.

2023-03-15

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Total Synthesis of Vilmoraconitine

Ji, J.; Chen, J.; Qin, S.; Li, W.; Zhao, J.; Li, G.; Song, H.; Liu, X.; Qin, Y. J. Am. Chem. Soc. 2023, 145, 3903-3908.

2023-03-08

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Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B

Hébert, M.; Bellavance, G.; Barriault, L. J. Am. Chem. Soc. 2022, 144, 17792-17796.

2023-03-01

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Total Synthesis of Hirsutellone B

Nicolaou, K. C.; Sarlah, D.; Wu, T. R.; Zhan, W. Angew. Chem. Int. Ed. 2009, 48, 6870–6874.

2023-02-22

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Total Synthesis of (-)-Daphenylline

Xu, B.; Wang, B.; Xun, W.; Qiu, F. G. Angew. Chem. Int. Ed. 2019, 58, 5754–5757.

2023-02-15

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Total Synthesis of Yuzurine-type Alkaloid Daphgraciline

Li, L.-X.; Min, L.; Yao, T.-B.; Ji, S.-X.; Qiao, C.; Tian, P.-L.; Sun, J.; Li, C.-C. J. Am. Chem. Soc. 2022, 144, 18823–18828.

2023-02-09

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Total Synthesis of Puberuline C

Shimakawa, T.; Nakamura, S.; Asai, H.; Hagiwara, K.; Inoue, M. J. Am. Chem. Soc. 2023, 145, 600–609.

2023-02-01

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Enantioselective Total Synthesis of (+)-Aberrarone

Amberg, W. M.; Carreira, E. M. J. Am. Chem. Soc. 2022, 144, 15475–15479.

2023-01-26

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Total Synthesis of the Chlorinated Pentacyclic Indole Alkaloid (+)-Ambiguine G

Hu, L.; Rawal, V. H. J. Am. Chem. Soc. 2021, 143, 10872–10875.

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2023-01-15

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Total Synthesis of Farnesin through an Excited-State Nazarov Reaction

Que, H. Y.; Shao, H.; He, H.; Gao, S. Angew. Chem. Int. Ed. 2020, 59, 7444–7449.

2022-12-08

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Enantioselective Total Synthesis of (+)-Tricycloclavulone

Ito,H.;* Hasegawa, M.; Takenaka, Y.; Kobayashi, T.; Iguchi, K.* J. Am. Chem. Soc. 2004, 126, 4520–4521.

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2022-12-01

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An eight-step gram-scale synthesis of (−)-jiadifenolide

Lu, H.; Martinez, M.; Shenvi, R. Nat. Chem. 2015, 7, 604–607.

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2022-11-22

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Asymmetric Total Syntheses of Hypoestin A, Albolic Acid, and Ceroplastol II

Wang, Y.; Xu, K.; Min, L.; Li, C. J. Am. Chem. Soc. 2022, 144, 10162–10167.

2022-11-10

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Unified Total Synthesis of Pyrroloazocine Indole Alkaloids Sheds Light on Their Biosynthetic Relationship

Miloserdov, F. M.; Kirillova, M. S.; Muratore, M. E.; Echavarren, A. M. J. Am. Chem. Soc. 2018, 140, 5393–5400.

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2022-11-03

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Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (–)-Longirabdolactone, and (–)-Effusin

Zhang, J.;Li, Z.; Zhuo, J.; Cui, Y.; Han, T.; Li, C. J. Am. Chem. Soc. 2019, 141, 8372–8380.

2022-10-27

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14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

Jørgensen, L.; McKerrall, S. J.; Kuttruff, C. A.; Ungeheuer, F.; Felding, J.; Baran, P. S. Science, 2013, 341, 878–882

2022-10-20

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Asymmetric Total Synthesis of Hispidanin A

Deng, H.; Cao, W.; Liu, R.; Zhang, Y.; Liu, B. Angew. Chem. Int. Ed. 2017, 56, 5849–5852.

2022-10-13

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Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy

Truax, N. J.; Ayinde, S.; Liu, J. O.; Romo, D. J. Am. Chem. Soc. 2022, 144, 18575-18585

2022-09-22

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Enantioselective Total Synthesis of Cotylenin A

Uwamori, M.; Osada, R.; Sugiyama, R.; Nagatani, K.; Nakada, M. J. Am. Chem. Soc. 2020, 142, 5556–5561.

2022-09-08

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Synthesis of (+)-CP-263,114

Chen, C.; Layton, M. E.; Sheehan, S. M.; Shair, M. D. J. Am. Chem. Soc. 2000, 122, 7424-7425.

2022-09-01

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Enantioselective Total Synthesis of (+)-Euphorikanin A

Classen, M. J.; Böcker, M. N. A.; Roth, R.; Amberg, W. M.; Carreira, E. M. J. Am. Chem. Soc. 2021, 143, 8261–8265.

2022-08-25

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Total Syntheses of (–)-Acutumine and (–)-Dechloroacutumine

King, S. M.; Calandra, N. A.; Herzon, S. B. Angew. Chem. Int. Ed. 2013, 52, 3642–3645.

2022-08-18

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Total Synthesis of (+)-6-epi-Ophiobolin A

Thach, D. Q.; Brill, Z. G.; Grover, H. K.; Esguerra, K. V.; Thompson, J. K.; Maimone, T. J. Angew. Chem. Int. Ed. 2020, 59, 1532–1536.